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Search: WFRF:(Loos Ruth J F) > Luan Jian'an > Genome-wide meta-an...

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Kilpelainen, Tuomas O. (author)
Carli, Jayne F. Martin (author)
Skowronski, Alicja A. (author)
show more...
Sun, Qi (author)
Kriebel, Jennifer (author)
Feitosa, Mary F. (author)
Hedman, Asa K. (author)
Drong, Alexander W. (author)
Hayes, James E. (author)
Zhao, Jinghua (author)
Pers, Tune H. (author)
Schick, Ursula (author)
Grarup, Niels (author)
Kutalik, Zoltan (author)
Trompet, Stella (author)
Mangino, Massimo (author)
Kristiansson, Kati (author)
Beekman, Marian (author)
Lyytikainen, Leo-Pekka (author)
Eriksson, Joel (author)
Henneman, Peter (author)
Lahti, Jari (author)
Tanaka, Toshiko (author)
Luan, Jian'an (author)
Del Greco M, Fabiola (author)
Pasko, Dorota (author)
Renström, Frida (author)
Willems, Sara M. (author)
Mahajan, Anubha (author)
Rose, Lynda M. (author)
Guo, Xiuqing (author)
Liu, Yongmei (author)
Kleber, Marcus E. (author)
Perusse, Louis (author)
Gaunt, Tom (author)
Ahluwalia, Tarunveer S. (author)
Sung, Yun Ju (author)
Ramos, Yolande F. (author)
Amin, Najaf (author)
Amuzu, Antoinette (author)
Barroso, Ines (author)
Bellis, Claire (author)
Blangero, John (author)
Buckley, Brendan M. (author)
Boehringer, Stefan (author)
Chen, Yii-Der I. (author)
de Craen, Anton J. N. (author)
Crosslin, David R. (author)
Dale, Caroline E. (author)
Dastani, Zari (author)
Day, Felix R. (author)
Deelen, Joris (author)
Delgado, Graciela E. (author)
Demirkan, Ayse (author)
Finucane, Francis M. (author)
Ford, Ian (author)
Garcia, Melissa E. (author)
Gieger, Christian (author)
Gustafsson, Stefan (author)
Hallmans, Goran (author)
Hankinson, Susan E. (author)
Havulinna, Aki S. (author)
Herder, Christian (author)
Hernandez, Dena (author)
Hicks, Andrew A. (author)
Hunter, David J. (author)
Illig, Thomas (author)
Ingelsson, Erik (author)
Ioan-Facsinay, Andreea (author)
Jansson, John-Olov (author)
Jenny, Nancy S. (author)
Jorgensen, Marit E. (author)
Jorgensen, Torben (author)
Karlsson, Magnus (author)
Koenig, Wolfgang (author)
Kraft, Peter (author)
Kwekkeboom, Joanneke (author)
Laatikainen, Tiina (author)
Ladwig, Karl-Heinz (author)
LeDuc, Charles A. (author)
Lowe, Gordon (author)
Lu, Yingchang (author)
Marques-Vidal, Pedro (author)
Meisinger, Christa (author)
Menni, Cristina (author)
Morris, Andrew P. (author)
Myers, Richard H. (author)
Mannisto, Satu (author)
Nalls, Mike A. (author)
Paternoster, Lavinia (author)
Peters, Annette (author)
Pradhan, Aruna D. (author)
Rankinen, Tuomo (author)
Rasmussen-Torvik, Laura J. (author)
Rathmann, Wolfgang (author)
Rice, Treva K. (author)
Richards, J. Brent (author)
Ridker, Paul M. (author)
Sattar, Naveed (author)
Savage, David B. (author)
Söderberg, Stefan (author)
Timpson, Nicholas J. (author)
Vandenput, Liesbeth (author)
van Heemst, Diana (author)
Uh, Hae-Won (author)
Vohl, Marie-Claude (author)
Walker, Mark (author)
Wichmann, Heinz-Erich (author)
Widen, Elisabeth (author)
Wood, Andrew R. (author)
Yao, Jie (author)
Zeller, Tanja (author)
Zhang, Yiying (author)
Meulenbelt, Ingrid (author)
Kloppenburg, Margreet (author)
Astrup, Arne (author)
Sorensen, Thorkild I. A. (author)
Sarzynski, Mark A. (author)
Rao, D. C. (author)
Jousilahti, Pekka (author)
Vartiainen, Erkki (author)
Hofman, Albert (author)
Rivadeneira, Fernando (author)
Uitterlinden, Andre G. (author)
Kajantie, Eero (author)
Osmond, Clive (author)
Palotie, Aarno (author)
Eriksson, Johan G. (author)
Heliovaara, Markku (author)
Knekt, Paul B. (author)
Koskinen, Seppo (author)
Jula, Antti (author)
Perola, Markus (author)
Huupponen, Risto K. (author)
Viikari, Jorma S. (author)
Kahonen, Mika (author)
Lehtimaki, Terho (author)
Raitakari, Olli T. (author)
Mellstrom, Dan (author)
Lorentzon, Mattias (author)
Casas, Juan P. (author)
Bandinelli, Stefanie (author)
Maerz, Winfried (author)
Isaacs, Aaron (author)
van Dijk, Ko W. (author)
van Duijn, Cornelia M. (author)
Harris, Tamara B. (author)
Bouchard, Claude (author)
Allison, Matthew A. (author)
Chasman, Daniel I. (author)
Ohlsson, Claes (author)
Lind, Lars (author)
Scott, Robert A. (author)
Langenberg, Claudia (author)
Wareham, Nicholas J. (author)
Ferrucci, Luigi (author)
Frayling, Timothy M. (author)
Pramstaller, Peter P. (author)
Borecki, Ingrid B. (author)
Waterworth, Dawn M. (author)
Bergmann, Sven (author)
Waeber, Gerard (author)
Vollenweider, Peter (author)
Vestergaard, Henrik (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Hu, Frank B. (author)
Slagboom, P. Eline (author)
Grallert, Harald (author)
Spector, Tim D. (author)
Jukema, J. W. (author)
Klein, Robert J. (author)
Schadt, Erik E. (author)
Franks, Paul W. (author)
Lindgren, Cecilia M. (author)
Leibel, Rudolph L. (author)
Loos, Ruth J. F. (author)
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2016
2016
English.
In: Nature Communications. - 2041-1723. ; 7
  • swepub:Mat__t
Abstract Subject headings
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  • Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P < 10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P < 5 x 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.

Subject headings

Medical and Health Sciences  (hsv)
Health Sciences  (hsv)
Public Health, Global Health, Social Medicine and Epidemiology  (hsv)
Medicin och hälsovetenskap  (hsv)
Hälsovetenskaper  (hsv)
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi  (hsv)

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Kilpelainen, Tuo ...
Carli, Jayne F. ...
Skowronski, Alic ...
Sun, Qi
Kriebel, Jennife ...
Feitosa, Mary F.
show more...
Hedman, Asa K.
Drong, Alexander ...
Hayes, James E.
Zhao, Jinghua
Pers, Tune H.
Schick, Ursula
Grarup, Niels
Kutalik, Zoltan
Trompet, Stella
Mangino, Massimo
Kristiansson, Ka ...
Beekman, Marian
Lyytikainen, Leo ...
Eriksson, Joel
Henneman, Peter
Lahti, Jari
Tanaka, Toshiko
Luan, Jian'an
Del Greco M, Fab ...
Pasko, Dorota
Renström, Frida
Willems, Sara M.
Mahajan, Anubha
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Guo, Xiuqing
Liu, Yongmei
Kleber, Marcus E ...
Perusse, Louis
Gaunt, Tom
Ahluwalia, Tarun ...
Sung, Yun Ju
Ramos, Yolande F ...
Amin, Najaf
Amuzu, Antoinett ...
Barroso, Ines
Bellis, Claire
Blangero, John
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Boehringer, Stef ...
Chen, Yii-Der I.
de Craen, Anton ...
Crosslin, David ...
Dale, Caroline E ...
Dastani, Zari
Day, Felix R.
Deelen, Joris
Delgado, Graciel ...
Demirkan, Ayse
Finucane, Franci ...
Ford, Ian
Garcia, Melissa ...
Gieger, Christia ...
Gustafsson, Stef ...
Hallmans, Goran
Hankinson, Susan ...
Havulinna, Aki S ...
Herder, Christia ...
Hernandez, Dena
Hicks, Andrew A.
Hunter, David J.
Illig, Thomas
Ingelsson, Erik
Ioan-Facsinay, A ...
Jansson, John-Ol ...
Jenny, Nancy S.
Jorgensen, Marit ...
Jorgensen, Torbe ...
Karlsson, Magnus
Koenig, Wolfgang
Kraft, Peter
Kwekkeboom, Joan ...
Laatikainen, Tii ...
Ladwig, Karl-Hei ...
LeDuc, Charles A ...
Lowe, Gordon
Lu, Yingchang
Marques-Vidal, P ...
Meisinger, Chris ...
Menni, Cristina
Morris, Andrew P ...
Myers, Richard H ...
Mannisto, Satu
Nalls, Mike A.
Paternoster, Lav ...
Peters, Annette
Pradhan, Aruna D ...
Rankinen, Tuomo
Rasmussen-Torvik ...
Rathmann, Wolfga ...
Rice, Treva K.
Richards, J. Bre ...
Ridker, Paul M.
Sattar, Naveed
Savage, David B.
Söderberg, Stefa ...
Timpson, Nichola ...
Vandenput, Liesb ...
van Heemst, Dian ...
Uh, Hae-Won
Vohl, Marie-Clau ...
Walker, Mark
Wichmann, Heinz- ...
Widen, Elisabeth
Wood, Andrew R.
Yao, Jie
Zeller, Tanja
Zhang, Yiying
Meulenbelt, Ingr ...
Kloppenburg, Mar ...
Astrup, Arne
Sorensen, Thorki ...
Sarzynski, Mark ...
Rao, D. C.
Jousilahti, Pekk ...
Vartiainen, Erkk ...
Hofman, Albert
Rivadeneira, Fer ...
Uitterlinden, An ...
Kajantie, Eero
Osmond, Clive
Palotie, Aarno
Eriksson, Johan ...
Heliovaara, Mark ...
Knekt, Paul B.
Koskinen, Seppo
Jula, Antti
Perola, Markus
Huupponen, Risto ...
Viikari, Jorma S ...
Kahonen, Mika
Lehtimaki, Terho
Raitakari, Olli ...
Mellstrom, Dan
Lorentzon, Matti ...
Casas, Juan P.
Bandinelli, Stef ...
Maerz, Winfried
Isaacs, Aaron
van Dijk, Ko W.
van Duijn, Corne ...
Harris, Tamara B ...
Bouchard, Claude
Allison, Matthew ...
Chasman, Daniel ...
Ohlsson, Claes
Lind, Lars
Scott, Robert A.
Langenberg, Clau ...
Wareham, Nichola ...
Ferrucci, Luigi
Frayling, Timoth ...
Pramstaller, Pet ...
Borecki, Ingrid ...
Waterworth, Dawn ...
Bergmann, Sven
Waeber, Gerard
Vollenweider, Pe ...
Vestergaard, Hen ...
Hansen, Torben
Pedersen, Oluf
Hu, Frank B.
Slagboom, P. Eli ...
Grallert, Harald
Spector, Tim D.
Jukema, J. W.
Klein, Robert J.
Schadt, Erik E.
Franks, Paul W.
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Leibel, Rudolph ...
Loos, Ruth J. F.
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